EGFR and neoplasm: For example, calcium-dependent activation of caspases and other hydrolytic enzymes [7], [12], [13], generation of reactive oxygen species (ROS) [14], topoisomerase inhibition [15], interference with signal transduction pathways (e.g. Src-mediated phosphorylation of epidermal growth factor receptor (EGFR) and induction of the cell cycle inhibitor p21Cip1[16] have all been associated with the anti-tumour effects of CGs.