CRYBB1 and nuclear cataract: Among these genes, αA-crystallin (CRYAA), βA1-crystallin (CRYBA1), βB1-crystallin (CRYBB1), βB2-crystallin (CRYBB2), γC-crystallin (CRYGC), γD-crystallin (CRYGD), connexin 46 (CX46), connexin 50 (CX50), and major intrinsic protein (MIP) are highly expressed in the lens and have been shown to be associated with nuclear cataract [1,4], and thus represent excellent candidate genes for hereditary nuclear cataracts.