In our study, it was found that MDDCs from subjects with rs4804803 AG genotype had higher surface DC-SIGN expression with higher production of chemokines such as IP-10, which could limit DEN-2 replication (Fig. 4A); however, the higher surface DC-SIGN expression in subjects with AG genotype decreased remarkably 24 h post-infection (Fig. 2A). This evidence concerns the gene CXCL10 and infection.