CD4 and infection: However, while specific IgG2a production in the absence of IL-4Rα signaling via CD4+ T cells in female LckcreIL-4Rα−/lox mice was significantly greater (p<0.025) than in infected control IL-4Rα−/lox mice as early as week 6 post-infection (Figure 3C) it was not until week 12 post-infection that male LckcreIL-4Rα−/lox mice were producing significantly more IgG2a (p<0.025) than their infected control IL-4Rα−/lox counterparts (Figure 3D).