The fact that knockdown of TLR3 by siRNA in RIG-I- and MDA5-knockdown cells (shRIG-I cells) further enhances dengue virus infection and reduces IFN-β response demonstrates that all the three pattern recognition receptors are implicated in host innate immune response to the same virus in a same infected cell, and may play a synergistic role. This evidence concerns the gene IFIH1 and dengue disease.