CASP3 and neoplasm: Although other cell death products have been assessed as PD biomarkers in lymphoma such as caspase 3 and cytochrome c (Barczyk et al, 2005; Deligezer et al, 2006), nDNA has the advantage that extensive validation and qualification of this assay has already been performed in other tumour types (Holdenrieder et al, 2008).