In agreement with previous microarray studies, the present study has demonstrated that IGFBP3 is overexpressed in pancreatic cancer and can differentiate cancerous from benign tissue (Iacobuzio-Donahue et al, 2002; Logsdon et al, 2003; Iacobuzio-Donahue et al, 2003a; Grutzmann et al, 2004; Missiaglia et al, 2004; Laurell et al, 2006). Here, IGFBP3 is linked to familial pancreatic carcinoma.