The other results were different: 24.9% in all AML cases,33 74.3% in normal-karyotype AMLs34 or 52.9% in normal-karyotype AMLs.10 In fact, in spite of relative differences in frequencies of these mutations, all studies imply a higher frequency of NPM1 mutations in AML cases with normal karyotype. Here, NPM1 is linked to acute myeloid leukemia.