To our knowledge, no direct effects of aldosterone on adiponectin and adiponectin receptors were observed despite the fact that both adiponectin receptors, adipoR1 and adipoR2, have been showed to be expressed in mouse adrenal gland and adrenocortical Y-1 cells [62] and in human adrenal cortex and aldosterone-producing adenoma tissue [63]. The gene discussed is ADIPOR2; the disease is adenoma.