In the brain of a mouse model (JNPL3 mouse) [56] for neurodegeneration (frontotemporal dementia and parkinsonism linked to chromosome 17; FTDP-17), where neurodegeneration and neuroinflammation are induced through transgenic expression of a mutated human tau gene (htau P301L), EFhd2 was identified in a complex with the transgenic human tau protein [15]. This evidence concerns the gene MAPT and semantic dementia.