IL18 and obesity due to melanocortin 4 receptor deficiency: In our series, IL-18 concentration had positive correlation with T, and linear regression analysis showed that serum IL-18 concentration was determined by T, BMI and HOMA IR, but especially by T. Moreover, it seemed that hyperandrogenism was correlated with serum level of IL-18, and it is a crucial factor of increased level of IL-18, which might be the reason for PCOS patients who without insulin resistance and obesity have elevated IL-18, but the mechanism of it has not been clear, it need future study.