Moreover, since IL18 was a proinflammatory cytokine and a strong risk marker for cardiovascular disease, whether we can use anti-inflammatory drug to reduce the serum level of IL18 and consequently decrease the incidence of PCOS, which may shred a new light on prevention or treatment of PCOS, but it is still need be further investigated based on large population. This evidence concerns the gene IL18 and polycystic ovary syndrome.