In another study, Sheng et al. [89] observed that LRRK2 knock-out in zebrafish by morpholinos is embryonically lethal while deletion of the C-terminal WD40 domain induces a parkinsonism-like loss of neurons and locomotive defects, indicating that LRRK2 function is essential for neuronal survival. The gene discussed is LRRK2; the disease is Parkinsonism.