Additionally, the CK14+/CK8+ cancer cells in the PIN and CaP lesions (Figure 5C; arrow-indicated in (h) and (i)) might be originated from CK14(low or -)/CK8- cells in the normal prostates (Figure 5C; arrowhead-indicated in (g)), and then differentiated into CK14low/CK8(high or +) progeny (Figure 5C; arrowhead-indicated in (i)). The gene discussed is KRT14; the disease is cancer.