Comparably, the CK14+/CD44+ cancer cells in the PIN and CaP lesions (Figure 5C; arrow (2)-indicated in (e) and (f)) were likely to be originated from CK14(low or -)/CD44(low or -) cells in the normal prostates (Figure 5C; arrowhead-indicated in (d)) or from CK14+/CD44(low or -) cells (Figure 5C; arrow (1)-indicated in (e) and (f)) and CK14(low or -)/CD44+ cells (Figure 5C; arrow (3)-indicated in (e) and (f)), as the cells were transformed into PIN and progressed into CaP conditions. This evidence concerns the gene CD44 and prostate intraepithelial neoplasia.