Firstly, the entire process of prostate tumorigenesis was reconstituted in vivo and the effects of Hh overexpression on the normal prostate stem cells was shown by the transformation of P63+/Patch1(Low or -) and P63+/Smo (Low or -) quiescent basal cells into the P63+/Patch1+ and P63+/Smo+ hyperplastic basal cells, comparable to the human BCH condition that had been previously observed [20]. The gene discussed is SMO; the disease is choreatic disease.