Another important mechanism linking CV disease and osteoporosis is Wnt signalling, a combination of the genes Wg (wingless) and Int. Animal models showed the important role of Wnt signalling in bone formation through lipoprotein receptor-related protein 5 (LRP5), lipoprotein receptor-related protein 6 (LRP6) and β-catenin [114]. The gene discussed is INTU; the disease is osteoporosis.