The development of obesity is associated with chronic inflammatory status, coinciding with significantly increased macrophage infiltration in adipose tissue and the expression of inflammatory cytokines, such as TNF-α, IL-6, monocyte chemotactic protein-1, and plasminogen activator inhibitor type-1 (PAI-1) [6]. This evidence concerns the gene SERPINE1 and obesity due to melanocortin 4 receptor deficiency.