FZD5 and interstitial lung disease: Several differentially expressed genes between ILD samples and controls in Wnt pathway are heavily targeted by DEmiRNAs; for example, F-box and WD repeat domain containing 11 (FBXW11) and frizzled homolog 5 (FZD5) (Figure 3, green circles) were down-regulated and likely were "targeted" by up-regulated DEmiRNAs (Figure 3, red triangles) such as miR-199-3p and miR-200b, while the nuclear factor of activated T-cells 5 (NFAT5) is up-regulated and targeted by down-regulated DEmiRNAs including miR-30 family members and others (Figure 3, green triangles).