HFD and HSD caused significant elevation in serum creatinine a specific indicator of glomerular function and urea level (Table 1) owing to consumption of HFD and HSD which result in metabolic syndrome marked by obesity, hyperlipidemia and associated with oxidative stress and nitric oxide inactivation by reactive oxygen species (ROS) and diminish NO bioavailability [24] which leading to renal dysfunction, characterizing by high level of creatinine and blood urea nitrogen [25]. The gene discussed is CHST3; the disease is obesity due to melanocortin 4 receptor deficiency.