We could concluded that HFD and HSD induced obesity, represent the best available rat model to study nephropathy, which riskily affect the kidney via elevating urea, creatinine, TG, LDL and glucose and that the renal injuries were associated with increased oxidative stress monitored by increased MDA level and catalase activity whereas NO production decreases while using garcinia cambogia improved the levels of blood lipid profile, oxidative stress, biomarkers and glucose so improving kidney function. The gene discussed is CAT; the disease is obesity due to melanocortin 4 receptor deficiency.