HFD and HSD caused significant elevation in serum creatinine a specific indicator of glomerular function and urea level (Table 1) owing to consumption of HFD and HSD which result in metabolic syndrome marked by obesity, hyperlipidemia and associated with oxidative stress and nitric oxide inactivation by reactive oxygen species (ROS) and diminish NO bioavailability [24] which leading to renal dysfunction, characterizing by high level of creatinine and blood urea nitrogen [25]. This evidence concerns the gene CHST3 and Obesity.