Those cognitive deficits began as early as 3 months (5.7 ± 0.6 trials and 11.0 ± 0.5 seconds for APPswe/PS1 vs 14.2 ± 2.4 trials and 14.0 ± 1.3 seconds for APPswe/PS1-MyD88+/-) and evolved rapidly at 6 (13.0 ± 1.0 trials and 13.5 ± 0.7 seconds for APPswe/PS1 mice vs 30.1 ± 3.5 trials and 18.9 ± 1.9 seconds for APPswe/PS1-MyD88+/- mice) and 9 months (18.4 ± 1.7 trials and 17.0 ± 1.9 seconds for APPswe/PS1 vs 34.7 ± 3.7 trials and 22.0 ± 1.5 seconds for APPswe/PS1-MyD88+/-). This evidence concerns the gene MYD88 and Cognitive impairment.