Disorders in the UMOD gene lead to the early onset of severe kidney disease.[3] A more common variant in the UMOD genotype has been associated with lower risk of CKD in persons of European descent.[1] Higher urine concentrations of uromodulin were associated with subsequent development of CKD in the FHS, a community-based, predominantly White study.[5] However, in this study from the Heart and Soul cohort of persons with established CAD, we found no association between urine concentrations of uromodulin or total daily uromodulin and incident CKD. The gene discussed is UMOD; the disease is kidney disorder.