UMOD and chronic kidney disease: Disorders in the UMOD gene lead to the early onset of severe kidney disease.[3] A more common variant in the UMOD genotype has been associated with lower risk of CKD in persons of European descent.[1] Higher urine concentrations of uromodulin were associated with subsequent development of CKD in the FHS, a community-based, predominantly White study.[5] However, in this study from the Heart and Soul cohort of persons with established CAD, we found no association between urine concentrations of uromodulin or total daily uromodulin and incident CKD.