Merlin (moesin-ezrin-radixin-like protein), the product of the neurofibromatosis type 2 (NF2) gene, is another member of the Protein 4.1 superfamily that has an established function as a schwannoma and meningioma tumor suppressor protein, with NF2 mutations also seen in cases of thyroid cancer, mesothelioma, and melanoma [21]. Here, NF2 is linked to melanoma.