CXCR4 and osteosarcoma: In a heterogeneous group of malignant nonround cell tumors, which included synovial sarcoma, malignant peripheral nerve sheath tumor, leiomyosarcoma, MFH, liposarcoma, fibrosarcoma, angiosarcoma, clear cell sarcoma, epithelioid sarcoma, osteosarcoma, and chondrosarcoma, high CXCR4 mRNA expression was an independent predictor of poor prognosis by univariate and Cox multivariate analysis [30].