TP53 and cancer: All patients developed cancer after first detection of anti-p53 autoantibodies and the serological response remained detectable throughout the remaining course of the disease [8] In light of such data, p53-specific autoantibodies would seem to be very well suited for diagnostic purposes [19, 20] and, accordingly, anti-p53 autoantibodies have been extensively studied regarding their diagnostic and prognostic applicability for a wide variety of malignancies [21–23].