IL6 and rheumatoid arthritis: Alternatively, adiponectin has been described as a potent proinflammatory mediator, as it has been shown to stimulate the production of IL-6 and prostaglandin E2 by synovial fibroblasts in rheumatoid arthritis patients, with serum adiponectin levels correlating to the severity of rheumatoid arthritis evaluated by the extent of joint destruction [18–20].