RYR2 and catecholaminergic polymorphic ventricular tachycardia: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is characterized by ventricular ectopy induced by exercise or emotional stress.[38] It is a genetic channelopathy, most commonly caused by mutations of the ryanodine receptor gene (RYR2) which encodes a sarcoplasmic calcium ion channel.[39] The onset of CPVT symptoms typically occurs in childhood and adolescence.