INS and Insulin resistance: A significant reduction in post-glucose insulin values was seen after treatment with metformin, an insulin sensitizer, which is known to reduce insulin resistance and accordingly improves clinical, hormonal and metabolic parameters.[3] Metformin therapy showed significant improvement in BMI but WHR was not improved in this study as also seen in the study of Velazquez et al.,[9] Most important change was seen in the menstrual pattern and 52% of women having irregular menstrual cycle achieved regular cycles.