Furthermore, the combination of 15d-PGJ2 and 9-cis-retinoic acid (RA), the ligand for RXR, resulted in enhanced amelioration of disease, suggesting that combination of RXR-specific ligands and PPARγ ligands may be highly effective in the treatment of autoimmune demyelinating diseases such as MS [44]. The gene discussed is PPARG; the disease is myeloid sarcoma.