BRCA1 and breast cancer: The families with three or more ovarian cancers and at least one breast cancer had mutations in BRCA1 and BRCA2 in 81% of cases (similar to our results) while in the families with three or more ovarian cancers and no breast cancer mutations in BRCA1 or BRCA2 were detected in only 63% (which is still much higher than in our study) [34,35].