In the full group of currently smoking subjects, the A-allele of rs1051730 was associated with increased FTND score, while neither SNP in the CHRNA3/5 region (rs8034191 and rs1051730) was associated with FEV1 (% predicted), affection status of COPD, nor percent of emphysema (Table 5). This evidence concerns the gene CHRNA3 and pulmonary emphysema.