Moreover, TSN also has anticancer properties evidenced by inhibiting the proliferation of mouse P388 lymphocytic leukemia cells [22], and inducing apoptosis of human hepatocellular carcinoma cells [23], etc. Although cardiomyocyte apoptosis and inflammatory reaction were increased in experimental model of diabetic cardiomyopathy and TSN has anti-apoptosis and anti-inflammation properties. The gene discussed is TSN; the disease is diabetic cardiomyopathy.