Concurrently, levels of caspase-3 activity were determined and we found that TSN group showed significantly decreased caspase-3 enzymatic activity compared with the diabetes group (55.0 ± 20.7 vs 101.7 ± 22.0, P < 0.05) and the HOE140 group (55.0 ± 20.7 vs 98.9 ± 22.3, P < 0.05) (Figure 2C). The gene discussed is CASP3; the disease is diabetes mellitus.