Furthermore, the ratios of CD4+ or CD8+ T cells to Treg was twofold and sixfold higher, respectively, in the tumors of the α-TEA-treated animals at day 18 compared with the control mice, and these data corroborate previous reports in which higher CD8+ cytotoxic T cell-to-Treg ratios in the tumor or in lymphoid organs were associated with improved prognosis [44-46]. This evidence concerns the gene CD8A and neoplasm.