CCN1 and pancreatic adenocarcinoma: To establish whether Cyr61 is indeed a critical signaling factor in PDAC, we have studied the expression profile of Cyr61 in human pancreatic adenocarcinoma samples and different cell lines at protein and mRNA levels; and determined its functional role in the development and progression of pancreatic adenocarcinoma by silencing Cyr61 retrovirally or exposing cells to recombinant Cyr61 protein.