The studies clearly implicate Cyr61 as an important factor in determining PDAC aggressiveness as it promotes epithelial to mesenchymal transition (EMT), tumor stemness, in vitro migration and tumorigenicity in xenograft model, possibly through the regulation of multiple miRNAs that are known to link with the progression of cancers and survival and the maintenance of cancer stem cells [18,19]. Here, CCN1 is linked to cancer.