Besides being a confounding factor, we can hypothesize that mutation of E-cadherin (CDH1), or other mechanisms disrupting the CDH1 gene function such as epigenetic mechanisms or miRNAs, playing an important role in diffuse type gastric cancer, might play a minor role in SA gastric cancer patients due to different pathways of carcinogenesis, as shown in the present study by differences in patterns of DNA copy number aberrations. The gene discussed is CDH1; the disease is gastric cancer.