Because the stoichiometric concentration of TFs within the nucleus may control gene expression [43], this association proposes a link between obesity and TCF12 through ZNF639. Because ZNF639 regulates anchoring of E-cadherin to the cytoskeleton through alpha N-catenin [76], given the importance of cell adhesion proteins in cancer [77], future studies of endometrial cancer might focus on ZNF639. This evidence concerns the gene ZNF639 and obesity due to melanocortin 4 receptor deficiency.