In addition, Almeda-Valdes P et al. showed that total adiponectin, high molecular weight adiponectin (HMWA) and the HMWA/total adiponectin index had similar utility for identifying insulin resistance and metabolic disturbances [33], but whether clinical differences exist between them for predicting risk of coronary atherosclerosis is still unclear. The gene discussed is ADIPOQ; the disease is coronary atherosclerosis.