Recently, The UK Collaborative HIV Cohort (UK CHIC) Steering Committee defined presentation at a stage when there is a substantial risk of death (i.e., CD4 counts <200/mm3 or clinically-defined AIDS) as presentation with "advanced HIV disease" and presentation with a CD4 cell count below 350/mm3, resulting in a delay in treatment initiation, as "late presentation"[7]. The gene discussed is CD4; the disease is AIDS.