TNFRSF1A and TNF receptor 1-associated periodic fever syndrome: We also showed that the incidence and the frequency of the most typical TRAPS-related clinical manifestations (chest pain, abdominal pain, rash, limb pain, and periorbital edema) in patients with the R92Q variant were much more similar to those observed in patients with PFAPA than those observed in patients with structural TNFRSF1A mutations.