BMP7 and osteosarcoma: On the other hand, BMP-7 expression has been identified and clinical features of BMP-7 expression in several human cancers such as osteosarcoma, malignant melanoma, breast cancer, prostate cancer, colorectal cancer and renal cell cancer have been discussed (Sulzbacher et al, 2002; Masuda et al, 2004; Alarmo et al, 2006; Kwak et al, 2007; Rothhammer et al, 2007; Motoyama et al, 2008 ).