A subsequent report showed that APCMin/+;Tgfbr1+/− mice developed twice as many intestinal tumours and colonic carcinomas as APCMin/+;Tgfbr1+/+, supporting the role of TGFBR1 gene haploinsufficiency in CRC development (Zeng et al, 2009). The gene discussed is TGFBR1; the disease is intestinal neoplasm.