A subsequent report showed that APCMin/+;Tgfbr1+/− mice developed twice as many intestinal tumours and colonic carcinomas as APCMin/+;Tgfbr1+/+, supporting the role of TGFBR1 gene haploinsufficiency in CRC development (Zeng et al, 2009). This evidence concerns the gene TGFBR1 and colon carcinoma.