Our findings, in association with the fact that ABI3 expression is frequently lost in invasive cancer cell lines, and that ABI3 re-expression markedly inhibited cell motility and significantly reduced the formation of tumor metastasis in vivo [3], suggest that ABI3 loss of expression may play an important role in the pathogenesis and/or progression of several tumors subtypes. This evidence concerns the gene ABI3 and neoplasm.