So far, the PON2 reports mainly examined these two coding polymorphisms, of which the rs6954345 (p.Ser311Cys) SNP was found to be associated with several cardiovascular complications [14-16] and renal dysfunction [17], whereas the rs11545941 (p.Ala148Gly) SNP associated with plasma lipoprotein levels in some studies [18]. Here, PON2 is linked to Abnormal renal physiology.