Significant results obtained from stepwise linear regression analysis of serum PON activity (square root transformed) with SLE disease status, age, BMI, smoking, PON1/rs662 (p.Gln192Arg), PON1/rs854560 (p.Leu55Met) and PON3/rs17884563 SNPs and 13 PON2 tagSNPs. The gene discussed is PON2; the disease is systemic lupus erythematosus.