HIV-1 NL4-3 replication was inhibited by 75 ± 6.1% on day 3 and 69 ± 6.4% on day 4 after infection compared to virus replication in HeLa SS6 cells transfected with the control vector pLRed(INS)2R-CD4 (Figure 4B,C). The gene discussed is CD4; the disease is infection.