We present the case of a patient with slow right ventricular (RV) conduction in the presence of a truncation mutation in DSC2 and a missense variant in DSG2. Analysis of endomyocardial tissue from this patient revealed that molecular changes in protein expression and phosphorylation may precede an overt ARVC phenotype. This evidence concerns the gene DSC2 and arrhythmogenic right ventricular cardiomyopathy.