MMP14 and prostate adenocarcinoma: For MT1-MMP, positive staining (weak to strong positive) was present in the cytoplasm (majority) and in the nucleus (small numbers) in tumor cells of prostate adenocarcinoma (Figure 4B), whereas only weak staining (0-1+) in the cytoplasm or nuclei of the glandular epithelium could be seen in normal prostate tissues (Figure 4A).