MMP14 and neoplasm: A positive correlation in the nuclear expression (staining) of LIMK1 and MT1-MMP in grade 3 and grade 4 tumors, which increased from 20% (grade 3 tumors) to 40% (LIMK1) and 45%(MT1-MMP)(grade 4 tumors) of the tumor samples stained, was also noted (additional file 2).