ADIPOQ and obesity due to melanocortin 4 receptor deficiency: In addition, most of the studies performed so far have been cross-sectional and have only included few SNPs in the region of ADIPOQ. The aim of the present study was to provide supportive evidence for the involvement of ADIPOQ variation in T2DM and obesity related phenotypes and serum adiponectin levels in the prospective Finnish Diabetes Prevention Study (DPS).