Other investigators have reported that IGF-I accelerates the expression of VEGF in some cell lines.[6] Smith and associates have reported that inhibition of GH can inhibit ischaemia induced retinal neovascularisation in vivo via vascular endothelial growth factor (VEGF).[7] Thus growth hormone may play a major role in the progression of diabetic retinopathy in combination with IGF-I and VEGF. This evidence concerns the gene VEGFA and diabetic retinopathy.