FOXC1 and Axenfeld-Rieger syndrome: Axenfeld-Rieger anomaly, mapped to 6p25, is associated with mutations in the FKHL7 gene that codes a transcription factor containing a fork-head domain, the gene responsible is FOXC1.[14, 32] Initial localization of the RIEGl gene, responsible for Rieger syndrome, was aided by cases of 4q-deletion that also demonstrated the Rieger’s phenotype.