Intriguingly, no coding variations of the WDR36 gene were found in 2 of the 7 GLC1G linked families, indicating a possibility of non-coding variations or of another POAG gene at GLC1G.[66] New data resulting from discrepancies between the genetic and physical maps positioned the upper boundary for this locus to 5q21.3.[66, 67] Although the function of the protein Product of this gene is unknown and the role of this protein in glaucoma remains to be confirmed,[68] prior studies suggest that it may participate in immune responses. The gene discussed is WDR36; the disease is open-angle glaucoma.