Genome-wide scan of a large adult-onset POAG family spanning four generations mapped the GLC1F locus to 7q35–q36.[65] All 10 living patients in the family had POAG with grade IV gonioscopy, IOPs of 22 mm Hg or more, and vertical cup-disc ratios of 0.6 or more. Here, ASB10 is linked to open-angle glaucoma.