MYOC and open-angle glaucoma: Apolipoprotein E (APOE) had been reported to be a potent modifier gene for POAG.[79] The promoter polymorphism –219T>G was associated with increased optic nerve damage, while –491A>T interacted with a MYOC polymorphism, –1000C>G (MYOC.mt1), to increase IOP in POAG patients.