Most cases of HGPS result from a nucleotide position 1824C → T mutation (substitution mutation from cytosine to thymine) in the gene coding lamin A (LMNA) that creates an ectopic mRNA splicing site leading to an expression of truncated prelamin A. If compared to “normal” prelamin A protein, truncated prelamin A lacks 50 amino acids within its tail domain. The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.