But no association between a polymorphism in genes CYP17 (5′untranslated MspA1 polymorphism), CYP19 (generated by a G → T substitution in intron 6), involved in the sex hormone biosynthesis pathway, and Pvull (lipoprotein lipase) polymorphism (generated by a C → T substitution in intron 1) in the estrogen receptor ESR1 gene and the risk of breast cancer was demonstrated (Chen et al., 2008). This evidence concerns the gene ESR1 and breast carcinoma.