Moreover, mice with diminished expression of Beclin 1 and mice with inactivation of Atg7 in microglia/macrophages are susceptible to cerebral and ocular toxoplasmosis despite upregulation of IFN-γ, TNF-α and NOS2 as well as the induction of T cell-mediated immunity. This evidence concerns the gene BECN1 and ocular toxoplasmosis.