Here, single copies of both CDKN2A and miR-15a/16-1, the microRNA cluster deleted in >50% of CLL patients (Cimmino et al., 2005), were lost through interchromosomal rearrangements, whereas the other copy of the microRNA cluster was deleted in a presumably separate event (blue line, Figure 7C). The gene discussed is CDKN2A; the disease is B-cell chronic lymphocytic leukemia.