In addition to the loss of CDKN2A described above, the chordoma sample PD3808a had a rearrangement that directly disrupted WRN, linking the 3′ portion of this gene on chromosome 8 to an intergenic region on 9p just downstream of CDKN2A (thick purple line, Figure 7A). The gene discussed is CDKN2A; the disease is chordoma.